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Dyskinesia challenge - Michael J. Fox Foundation


The Michael J. Fox Foundation for Parkinson’s Research (MJFF) wishes to engage researchers and drug makers focused on studying and/or therapeutically treating levodopa-induced dyskinesia (LID). Applicants may submit a proposal focused on a relevant area of LID research (see full details below) for consideration of a one-year, $125,000 award. See the Special Requirements section below for additional information.


The Dyskinesia Challenge 2012 program seeks proposals focused on identifying and validating novel and innovative targets that will complement current MJFF efforts in the discovery and development of dyskinesia therapies


Current MJFF therapeutic development efforts focus on the following:

  • Serotonergic system: in order to control its inappropriate dopamine release, using partial 5-HT1A/1B agonists
  • Overactive glutamatergic system: with an antagonist of mGluR5 or with a selective activation of mGluR4
  • Enhanced MAP kinase signaling pathway: with inhibitors of RasGRF1
  • Nicotinic receptor subtypes: with selective ligands of the nicotinic acetylcholine receptors
  • Altered opioidergic neurotransmission: using mu opioid receptor antagonists

For the Dyskinesia Challenge RFA, MJFF is particularly interested in pre-clinical studies revealing new pathways, other than the above described targets already being thoroughly explored with MJFF support.

Termini oficial

No deadline; applications accepted anytime.

Termini IISPV

Termini IISPV: Cal comunicar abans que es vol participar a la convocatòria, enviant un e-mail a convocatories@iispv.cat . Termini: 11 de novembre de 2013

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