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Biomarkers of progression in the AT-Risk setting for Type 1 Diabetes 2013


JDRF International -JDRF is soliciting expressions of interest (EOI) to discover and develop candidate biomarkers of progression in the at-risk setting for type 1 diabetes (T1D). JDRF is committed and most interested in investigator-initiated proposals that focus on research with potential for clinical utility.


Expressions of interest are sought from investigators with access to existing samples and/or patient cohorts of individuals with ≥2 T1D autoantibodies to develop improved prognostic risk scores of progression and/or to develop new or improved screening assays. The translational potential of the investigations should be highlighted and thus, only research plans involving human samples will be considered.

The major focus of this EOI will be to identify candidate biomarkers that:
- Stage type 1 diabetes in the at-risk setting
- Predict risk/rate of progression
- Serve as surrogates of efficacy of preventive interventions
- Allow for inclusion/exclusion in clinical trials in the at-risk setting

Investigators with ideas or resources that might benefit this initiative should also submit their ideas via an expression of interest. Collaborative projects, where possible, to interrogate common sample sets are encouraged, and higher budgets may be allowed for such projects. Please contact JDRF prior to submission of an EOI for approval of such projects. JDRF recently released a request for letters of intent (LOIs) for Biomarkers of Pancreatic Beta Cell Stress and Health. This EOI is not meant as a replication of that LOI and EOIs in relation to beta cell stress and health will be considered only if they are relevant to the prevention setting. Furthermore, EOIs with a focus on autoantibody negative individuals only will not be considered.

Termini oficial

o Expression of Interest: ............................... November 1, 2013
o EOI Notification ........................................... November 8, 2013
o Application Due Date: ................................. December 18, 2013
o Response to Applicants Date: ................... March 2014
o Earliest Anticipated Start Date: ................. June 2014

Termini IISPV

Cal comunicar abans del 21 d’octubre de 2013 que es vol participar a la convocatòria, enviant un e-mail a europa@iispv.cat . Termini: 22 d’octubre de 2013. L'IISPV gestiona les ajudes dels seus investigadors, no és l'entitat convocant.

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